Triple antitubercular antibiotic therapy was initiated. Histology revealed granulomatous dermal lesions with eosinophilic necrosis. Antibiotic treatment comprising ofloxacin followed by rifampicin for two months proved ineffective. One week later, papular nodules appeared on the glans with a sclerosing lesion of the balanopreputial sac, dark purple perimeatal papules and a mass beneath the mucosa of the glans. Case 2: In a 61-year-old man receiving BCG therapy for relapsing bladder carcinoma in situ, the sixth instillation was considered traumatic since it was highly painful. Slow cure of the lesions was achieved within 12months using double antitubercular antibiotic therapy. Histology revealed epithelioid giant-cell granulomas. Three months later, examination revealed massive painful perimeatal ulceration with yellowish papules in the peripheral regions. One week after the seventh instillation, severe balanitis developed. Case 1: A 77-year-old man presented relapsing urothelial bladder carcinoma treated by endoscopic resection and BCG therapy. BCG infection of the glans is a rare local complication associated with this treatment, two cases of which are reported below. Therapy involves intravesical instillation of live attenuated Calmette-Guérin bacilli. Michelet, N Spenatto, N Viraben, R Cuny, J-F Mazet, J Trechot, P Barbaud, A Schmutz, J-LīCG therapy is an effective adjuvant treatment for superficial bladder tumors.
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